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US 4,052,511 AGranted
Carboxyacylproline derivatives
AssigneeE. R. Squibb & Sons, Inc.
InventorsDavid W. Cushman, Miguel Angel Ondetti
Life of this patent
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Abstract
New carboxyalkylacylamino acids which are derivatives of proline, pipecolic acid and azetidine-2-carboxylic acid and have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Claims28
A compound of the formula ##STR13## wherein R is hydroxy, amino or lower alkoxy;
- R.sub.1 and R.sub.4 each is hydrogen, lower alkyl or phenyl-lower alkyl;
- R.sub.2 is hydroxy, amino, hydroxyamino, or lower alkoxy;
- R.sub.3 is hydrogen, hydroxy or lower alkyl;
- m is 2;
- n is 0, 1 or 2
- and basic salts thereof, said lower alkyl and lower alkoxy groups having up to 7 carbons.
3 more elements
A compound of the formula ##STR14## wherein R is hydroxy or lower alkoxy;
- R.sub.1 is hydrogen, lower alkyl or phenyl-lower alkyl;
- R.sub.2 is hydroxy, hydroxyamino, lower alkoxy or phenyl-lower alkoxy;
- R.sub.4 is hydrogen or lower alkyl;
- n is 1 or 2;
- and
- physiologically acceptable salts thereof, said lower alkyl and lower alkoxy groups having up to 7 carbons.
3 more elements
Dependencies are inferred from the claim text.