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US 4,052,402 AGranted
Process for synthesizing codeinone from thebaine
AssigneeFabrica de Productos Quimicos y Farmaceuticos Abello, S.A.
InventorFernando Calvo
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Abstract
Codeinone is prepared by reacting thebaine with a hydrogen halide, under anhydrous conditions, in the presence of iodine as a catalyst, at a temperature of less than 10.degree. C, hydrolyzing the reaction product and recovering codeinone.
Drawings
Claims2
A process for preparing codeinone, which comprises the steps of:
- reacting thebaine dissolved in an inert halogenated hydrocarbon solvent, with hydrogen chloride or hydrogen bromide dissolved in an inert alkyl (C.sub.1 to C.sub.4) ether solvent, in the presence of iodine as a catalyst, under anhydrous conditions, to form a halogenated reaction product, then hydrolyzing the halogenated reaction product with an aqueous solution of sodium bicarbonate to transform the halogenated reaction product to codeinone, the reacting and hydrolyzing steps being carried out at temperatures below about 10.degree. C, and recovering codeinone from the product of the hydrolysis step.
Dependencies are inferred from the claim text.