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US 4,052,390 AGranted
Azapurinones
AssigneeMay & Baker Limited
InventorsBarbara Joyce Broughton, Bryan John Large, Stuart Malcolm Marshall, David Lord Pain, Kenneth Robert Harry Wooldridge
Life of this patent
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Abstract
8-Azapurin-6-ones substituted in the 2-position by a phenyl group carrying in a meta-position a sulphamoyl substituent, and also a hydroxy, alkoxy or alkylthio substituent para with respect to the said sulphamoyl grouping, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful in the treatment of allergic respiratory disorders, for example allergic bronchial asthma.
Claims5
An 8-azapurin-6-one of the formula:
- ##STR11## wherein R.sup.1 represents a member selected from the class consisting of hydroxy, alkoxy of 1 to 10 carbon atoms, and alkylthio of 1 to 10 carbon atoms, the group NR.sup.2 R.sup.3 represents piperidino, 1-pyrrolidinyl, or morpholino, and R.sup.4 represents hydrogen, methyl or ethyl, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.