Guanidine derivatives
AssigneeImperial Chemical Industries PLC
InventorDouglas Lintin Swallow
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Abstract
Guanidine derivatives of the formula: ##STR1## in which R.sup.1 is a cyclohexyl, adamantyl, bicycloheptanyl, bicycloheptenyl, tricycloheptanyl or tetracyclononanyl radical and R.sup.2 is a phenyl or pyridyl radical optionally substituted by 1 or 2 halogen atoms, or alkyl, cyanoalkyl, alkoxycarbonyl or amino radicals, and the pharmaceutically-acceptable acid-addition salts thereof, active against rhinoviruses, are disclosed, along with processes for their manufacture, compositions containing them, a method of combatting rhinoviral infections and a method of selectively killing rhinoviruses in a mixed virus population.
Claims10
A compound of the formula:
- ##STR13## wherein R.sup.1 is selected from the group consisting of adamantyl, bicyclo[2,2,1]heptanyl, bicyclo[2,2,1]hept-5-enyl, tricyclo[2,2,1,0.sup.2,6 ]heptanyl and tetracyclo[4,3,0,0.sup.2,4,0.sup.3,7 ]-nonanyl and R.sup.2 is selected from the group consisting of phenyl optionally substituted by a substituent selected from the group consisting of halogen, alkyl and cyanoalkyl of 1 to 6 carbons, alkoxycarbonyl of 2 to 6 carbons and amino, and the pharmaceutically-acceptable acid-addition salts thereof.
2-Exo-[3-(p-chlorophenyl)guanidino]bicyclo[2,2,1]hept-5-ene and the pharmaceutically-acceptable acid-addition salts thereof.
2-Exo-[3-(p-fluorophenyl)guanidino]bicyclo[2,2,1]-hept-5-ene and the pharmaceutically-acceptable acid-addition salts thereof.
Dependencies are inferred from the claim text.