Back to results
US 4,051,251 AGranted
Novel anti-hypertensive compositions
AssigneeMerck & Co., Inc.
InventorClement A. Stone
Life of this patent
Estimating the term…
Abstract
Novel pharmaceutical compositions comprising hydrazino-phenylpropionic acid decarboxylase inhibitors and certain benzimidazole and benzoxazole alanines are disclosed. The compositions have enhanced hypotensive activity.
Claims7
A pharmaceutical composition for treating hypertension comprising
- A. a decarboxylase inhibitor compound having the formula ##STR13## wherein R, R.sub.1, R.sub.2 and R.sub.3 are independently selected from hydrogen and C.sub.1 -C.sub.4 alkyl, and pharmaceutically acceptable salts thereof and
- B. an arylalanine selected from compounds having the formulae:
- ##STR14## wherein R.sub.4, R.sub.5, R.sub.7 and R.sub.8 are independently selected from hydrogen and C.sub.1 -C.sub.4 alkyl, R.sub.6 is selected from the group consisting of hydrogen, halogen, hydroxy and C.sub.1 -C.sub.4 alkyl, and pharmaceutically acceptable salts thereof, and ##STR15## wherein R.sub.9, R.sub.10, and R.sub.11 are independently selected from hydrogen and C.sub.1 -C.sub.4 alkyl, X is ##STR16## wherein R.sub.12 is hydrogen or C.sub.1 -C.sub.4 alkyl and Z is =O or --O--R.sub.13 wherein R.sub.13 is selected from hydrogen or C.sub.1 -C.sub.4 alkly, and pharmaceutically acceptable salts thereof wherein the weight ratio of (A):(B) is about 400:1 to about 1:4.
Dependencies are inferred from the claim text.