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US 4,051,244 AGranted
2,4-Diamino 5-bromo 6-chloro pyrimidines, process for their preparation and use as pharmaceuticals
AssigneeMar-Pha Societe d'Etudes et d'Exploitation de Marques
InventorsGeorges Dominique Mattioda, Francois Louis Albert Rocquet
Life of this patent
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Abstract
Compounds of the general formula ##STR1## wherein R.sub.1 and R.sub.3 represent hydrogen or alkyl containing 1 to 4 carbons; R.sub.2 and R.sub.4 represent hydrogen, alkyl containing 1 to 8 carbons, dialkylaminoalkyl or aryl, ##STR2## may also represent the piperazinyl group which may be substituted in the 4 position by methyl, phenyl or benzyl. Compounds have pharmaceutical utility.
Claims17
A compound of the general formula:
- ##STR9## in which R.sub.1 represents hydrogen or alkyl containing from 1 to 4 carbons, R.sub.2 represents hydrogen, alkyl having 1 to 8 carbons, dialkylaminoalkyl or aryl, and ##STR10## is piperazinyl which may be substituted in position 4 by methyl or benzyl, or when R.sub.3 represents hydrogen or alkyl having 1 to 4 carbons, and when R.sub.4 represents hydrogen, alkyl having 1 to 8 carbons, dialkylaminoalkyl or aryl, then ##STR11## is piperazinyl which may be substituted in position 4 by methyl or benzyl.
The compound 2-isopropylamine 4-(N-methylpiperazinyl) 5-bromo 6-chloro pyrimidine.
Dependencies are inferred from the claim text.