2-Naphthylacetic acid derivatives and compositions and methods thereof
AssigneeSyntex Corporation
InventorsJohn H. Fried, Ian T. Harrison
Life of this patent
Estimating the term…
Abstract
2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.
Claims9
A compound selected from the group of compounds represented by the formula:
- ##STR9## wherein R.sup.4 is aryl, and the corresponding esters, and pharmaceutically accepted addition salts thereof.
6-Phenyl-2naphthylacetic acid.
A method of effecting treatment of inflammation, pain, pyrexia, and pruritus which comprises administering an effective therapeutic dose of a compound selected from the group of compounds represented by the formula:
- ##STR10## wherein R.sup.18 is aryl, or a corresponding ester or pharmaceutically acceptable addition salts thereof.
A pharmaceutical composition for use in effecting treatment of inflammation, pain, fever, and itching which comprises a pharmaceutically acceptable non-toxic excipient and a therapeutically effective amount of a compound represented by the formula:
- ##STR11## wherein R.sup.18 is aryl, or a corresponding ester or pharmaceutically acceptable addition salt thereof.
Dependencies are inferred from the claim text.