Phenoxyalkanol derivatives
AssigneeMerck Patent GmbH
InventorsErich Schacht, Werner Mehrhof, Zdenek Simane, Herbert Nowak
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AssigneeMerck Patent GmbH
InventorsErich Schacht, Werner Mehrhof, Zdenek Simane, Herbert Nowak
Estimating the term…
Phenoxylakanols of the formula ##STR1## wherein R.sup.1 is H or CH.sub.3 ; R.sup.2 is CH.sub.3 or C.sub.6 H.sub.5 ; R.sup.3 is 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindoline, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydro-1-R.sup.5 -4-quinolyl, 4-chromanyl, 4-thiochromanyl, or, when at least one of R.sup.1 and R.sup.2 is other than CH.sub.3, also Hal, phenyl, 4-Hal-phenyl or 4-Hal-phenoxy, wherein R.sup.4 is H or alkanoyl of 2-4 carbon atoms, R.sup.5 is H or CH.sub.3 and Hal if F, Cl or Br; and physiologically acceptable acid addition salts thereof possess pharmacological activity, particularly cholesterol, triglyceride and uric acid blood-level lowering activity and are also useful as intermediates for the production of the corresponding phenoxyacetic acids.
A compound selected from the group consisting of 2-[4-(4-chloro-phenoxy)-phenoxy]-propanol, 2-[4-(4-chlorophenoxymethyl)-phenoxy]-2-methyl-propanol, 2-[4-(4-chlorophenoxy)-phenoxy]-2-phenyl-propanol, 2-(4-biphenylyloxy)-2-phenyl-ethanol, 2-(4-biphenylyloxy)-2-phenyl-propanol, 2-(4'-chloro-4-biphenylyloxy)-2-phenyl-propanol, 2-(4-biphenylyloxy)-2-phenyl-ethyl acetate, 2-[4-(4-chlorophenoxy)-phenoxy]-propyl acetate, 2-[4-(4-fluorophenoxymethyl)-phenoxy]-2-methyl-propanol, and 2-[4-(4-chlorophenoxymethyl)-phenoxy]-propanol.
A compound of claim 1, 2-[4-(4-chlorophenoxymethyl)-phenoxy]-2-methyl-propanol.
Dependencies are inferred from the claim text.