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US 4,051,169 AGranted
Amino acid esters
AssigneeMerck & Co., Inc.
InventorWalfred S. Saari
Life of this patent
Estimating the term…
Abstract
Derivatives of .alpha.-methyl-3,4-dihydroxyphenylalanine which are useful in compositions as anti-hypertensive agents.
Claims22
A compound of the formula ##STR22## wherein n is 0, 1, 2 or 3;
- m is 0, 1, 2 or 3;
- A.sub.1 and A.sub.2 are individually H or a lower alkanoyl
- P.sub.1 and R.sub.2 are individually H or alkyl of 1 to 3 carbon atoms and;
- R.sub.3 is the radical X--R.sub.4
- wherein
- X is --O--, --S-- or --NH-- and
- R.sub.4 contains up to 21 carbon atoms and is (1) a hydrocarbon radical or (2) an acyl radical of an organic acyclic or non-heterocyclic, monocyclic carboxylic acid
- or a pharmaceutically acceptable acid addition salt thereof.
5 more elements
An ester of the L isomer of an amino acid, substantially free of the D isomer, having the formula ##STR27## wherein n is 0, 1, 2 or 3;
- m is 0, 1, 2 or 3;
- R.sub.1 and R.sub.2 are individually H or alkyl of 1 to 3 carbon atoms and;
- R.sub.3 the radical X--R.sub.4
- wherein
- X is --O--, --S--, or --NH-- and
- R.sub.4 contains up to 21 carbon atoms and is (1) a hydrocarbon radical or (2) an acyl radical of an organic acyclic or ion-heterocyclic, monocyclic carboxylic acid
- or a pharmaceutically acceptable acid addition salt thereof.
4 more elements
Dependencies are inferred from the claim text.