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US 4,051,160 AGranted
Cis-4,5-didehydro-11-deoxy-13,14-dihydro-PG compounds
AssigneeThe Upjohn Company
InventorsGordon L. Bundy, Norman A. Nelson
Life of this patent
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Abstract
This invention relates to a group of cis-4,5-didehydro-11-deoxy-PG.sub.1 analogs having variable chain length, optional methyl substitution in the methyl-terminated side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including ulcer treatment, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
Claims40
A compound of the formula ##STR1## or a mixture comprising that compound and the enantiomer thereof;
- WHEREIN W is ##STR2## wherein g is 2 to 4, inclusive;
- WHEREIN L.sub.1 is ##STR3## or a mixture of ##STR4## wherein R.sub.3 and R.sub.4 are hydrogen or methyl, being the same or different,
- Wherein M.sub.1 is ##STR5## wherein R.sub.5 and R.sub.6 are hydrogen or methyl, with the proviso that R.sub.5 is methyl only when R.sub.6 is hydrogen and R.sub.6 is methyl only when R.sub.5 is hydrogen;
- Wherein R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation;
- and
- Wherein R.sub.7 is --(CH.sub.2).sub.m --CH.sub.3, wherein m is one to 5, inclusive.
3 more elements
Dependencies are inferred from the claim text.