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US 4,051,147 AGranted
1-(Arylamino)-and 1-(arylimino)-pyrroles
AssigneeSterling Drug Inc.
InventorRobert E. Johnson
Life of this patent
Estimating the term…
Abstract
1-(Arylamino)pyrroles and 1-(arylimino)pyrroles, useful as antibacterial agents, are prepared by reaction of an arylhydrazine or arylhydrazone with a 2,5-di-lower-alkoxytetrahydrofuran or with an alkanedione; by reaction of a 1-arylaminopyrrole with an oxalyl dihalide followed by oxidative hydrolysis of the product; by condensation of a 1-aminopyrrole with a quinone; or by oxidation or reduction of a respective 1-(arylamino)pyrrole or 1-(arylimino)pyrrole.
Claims12
A compound having the formula:
- ##STR14## where R.sub.1 and R.sub.2 are each hydrogen or each lower-alkyl, or R.sub.1 is hydrogen and R.sub.2 is carboxyl;
- R.sub.3 is hydrogen, hydroxy, benzyloxy, halo, azido, amino, di-lower-alkylamino or lower-alkyl;
- R.sub.4 is hydrogen, lower-alkanoyl, benzoyl or lower-alkyl;
- X represents either a benzenoid nucleus fused to the phenyl ring at the positions indicated, or it represents two hydrogen atoms or one hydrogen atom and one of the groups R.sub.3, or two of the groups R.sub.3 ;
- R.sub.5 is hydrogen, lower-alkyl, lower-alkanoyl, benzoyl or benzyl;
- and n is one of the integers 1 and 2, and where the phenyl ring of the groups R.sub.4 and R.sub.5 when benzoyl can be substituted by lower-alkyl, lower-alkoxy or from one to two halogens, and where halo or halogen, all occurrences, represents fluorine, chlorine or bromine, and lower-alkyl, lower-alkoxy and lower-alkanoyl, all occurrences, have from one to four carbon atoms.
3 more elements
Dependencies are inferred from the claim text.