Process for the production of .alpha.-[2-(p-chlorophenoxy)-isobutyryl]-.beta.-nicotinoyl glycol ester
AssigneeMerz + Co. GmbH & Co.
InventorsArthur Scherm, Dezso Peteri
Life of this patent
Estimating the term…
Abstract
The application discloses a novel improved process for the production of .alpha.-[2-(p-chlorophenoxy)-isobutyl]-.beta.-nicotinoyl glycol ester, a known compound having a lipid-lowering effect, by the reaction of .alpha.-[2-chlorophenoxy)-isobutyryl]-.beta.-ethyl chloride ester with an alkali salt of nicotinic acid, preferably sodium nicotinate, preferably in a high-boiling polar or dipolar aprotic solvent, especially dimethylformamide, most preferably at a temperature of about 120.degree. - 180.degree. C., and most advantageously in refluxing dimethylformamide. An unpredictable increase in yields of the desired product over yields attainable by previously-available processes is thereby obtained.
Claims7
A process for the production of .alpha.-[2-(p-chlorophenoxy)-isobutyryl]-.beta.-nicotinoyl glycol ester in high yields which consists essentially of reacting [2-(p-chlorophenoxy)-isobutyryl]-.beta.-chloroethyl ester with an alkali metal salt of nicotinic acid in a polar or dipolar aprotic solvent having a boiling point between about 100.degree. C. and 200.degree. C.
Dependencies are inferred from the claim text.