Pyridine grignard derivatives
AssigneeJohn Wyeth & Brother Limited
InventorAdrian Charles Ward Curran
Life of this patent
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Abstract
The invention relates to magnesium halide derivatives of tetrahydroquinolines and related compounds. These are intermediates useful in the preparation of anti-ulcer agents.
Claims10
A compound of formula (II) ##STR7## wherein R.sup.1, R.sup.2 and R.sup.6 are independently hydrogen, alkyl of 1 to 6 carbon atoms, phenylalkyl of 7 to 12 carbon atoms, phenyl, alkylphenyl of 7 to 12 carbon atoms, alkoxyphenyl of 7 to 12 carbon atoms, or halophenyl, or R.sup.1 and R.sup.2 taken together, are trimethylene, tetramethylene or pentamethylene or an R.sup.7 substituted derivative thereof;
- R.sup.7 is hydrogen, alkyl of 1 to 6 carbon atoms, gem-dimethyl, phenylalkyl of 7 to 12 carbon atoms, phenyl, alkylphenyl of 7 to 12 carbon atoms, alkoxyphenyl of 7 to 12 carbon atoms, or halophenyl;
- m is 1 or 3;
- and
- Hal represents chlorine, bromine or iodine, with the proviso that when R.sup.1 and R.sup.2 or R.sup.2 and R.sup.6 are both alkyl, they are selected from normal and secondary alkyl groups.
A compound of formula (II) ##STR8## wherein R.sup.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl,
- R.sup.2 is hydrogen or alkyl of 1 to 6 carbon atoms,
- R.sup.6 is hydrogen or alkyl of 1 to 6 carbon atoms, or
- R.sup.1 and R.sup.2 taken together are trimethylene, tetramethylene, or pentamethylene or a R.sup.7 substituent derivative thereof,
- R.sup.7 is hydrogen, alkyl of 1 to 6 carbon atoms or gem-dimethyl (in the 5, 6 or 7 positions),
- m is 1 or 3, and
- Hal is chlorine, bromine or iodine, with the proviso that when R.sup.1 and R.sup.2 or R.sup.2 and R.sup.6 are both alkyl, they are selected from normal and secondary alkyl groups.
Dependencies are inferred from the claim text.