Amphotericin complexes containing oxalic acid and calcium
AssigneeE. R. Squibb & Sons, Inc.
InventorJulio Metzger
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Abstract
This invention relates to new forms of amphotericin B which comprise amphotericin B, an acid anion, and calcium ion. These new forms of amphotericin retain the activity of amphotericin and have the particular advantage of being soluble in acidic or alkaline solutions.
Claims4
A crystalline amphotericin B complex comprising about 1 mol of amphotericin B, from about 0.5 to about 20 mols of an anion of oxalic acid, and from about 0.2 to about 0.8 mol calcium ion, the complex having a solubility in water at pH 2 of 3.44 g/l, an infrared absorption band at 6.1-6.3 microns, and an E.sub.1.sup.1 U. V. absorption value of 1500 at 405 millimicrons.
Dependencies are inferred from the claim text.