Antiviral 2-amino-5-[1-(indol-3-yl)alkyl]-2-thiazolin-4-ones
AssigneeBeecham Group Limited
InventorsMichael Raymond Harnden, Nicholas David Wright
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Abstract
Thiazolinone analogues of indolmycin having anti-viral activity as well as a degree of antibacterial and antimycoplasmal activity in contrast to the known indolmycin which has only some antibacterial activity. Tautomers and a single enantiomer or mixture of enantiomers are included. Intermediates are described which are cyclized to produce the active antiviral substances. Suitable dosage forms and amounts are set forth and various routes of administration included including administration to the respiratory tract as by insufflation or inhalation.
Claims24
A compound of the formula (II):
- ##STR8## or a tautomer thereof wherein R.sup.1 is hydrogen or methyl and R.sup.2 is hydrogen, alkyl of 1 to 4 carbon atoms, or benzyl unsubstituted or substituted by one or two halogen atoms, methoxy or nitro groups.
A pharmaceutical composition useful for combatting infections caused by an RNA virus in the respiratory system of humans and animals which comprises an anti-virally effective amount of a compound of the formula (II):
- ##STR9## or a tautomer thereof wherein R.sup.1 is hydrogen or methyl and R.sup.2 is hydrogen, alkyl of 1 to 4 carbon atoms, or benzyl unsubstituted or substituted by one or two halogen atoms, methoxy or nitro groups, in combination with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.