Steroidal erythropoietic agents and therapeutic compositions and methods
AssigneeAkzona Incorporated
InventorHenry A. Strade
Life of this patent
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Abstract
The stimulation of erythropoiesis in humans and other warm-blooded animals is produced by administration of an effective amount of a compound selected from the group consisting of 3.alpha.-hydroxy-5.beta.-estrane-17-one, 3.beta.-hydroxy-5.beta.-estrane-17-one, and the 3 esters and 3 ethers thereof. The steroids are particularly advantageous in that they exhibit an unexpected low level of pyrogenicity as compared to etiocholanolone, a known pyrogen.
Claims7
Method for the stimulation of erythropoiesis in humans and other warm-blooded animals in need of such therapy which comprises administering an amount effective to produce such stimulation of a compound selected from the group consisting of 3.beta.-hydroxy-5.beta.-estrane-17-one, and the 3-esters thereof of inorganic acids and of organic carboxylic acids having 3 to 18 carbon atoms, and the 3-ethers thereof in which the ether group is selected from the group consisting of methoxy, ethoxy, propoxy, benzyloxy and phenylethoxy.
A pharmaceutical preparation in unit dosage form adapted for parenteral administration for the stimulation of erythropoiesis in humans and other warm-blooded animals, containing as its active ingredient an effective amount within the range from about 5 to about 500 mg. per dosage unit of a compound selected from the group consisting of 3.beta.-hydroxy-5.beta.-estrane-17-one, and the 3-esters thereof of inorganic acids and of organic carboxylic acids having 3 to 18 carbon atoms, and the 3-ethers thereof in which the ether group is selected from the group consisting of methoxy, ethoxy, propoxy, benzyloxy and phenylethoxy.
Dependencies are inferred from the claim text.