Zinc sulfadiazine and its use in the treatment of burns
AssigneeResearch Corporation
InventorCharles L. Fox, Jr.
Life of this patent
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Abstract
Zinc is essential in the complex process of wound healing. Zinc sulfadiazine promotes wound healing and controls infection. When taken into the body, such as by topical application to a wound surface, zinc sulfadiazine dissolves and its dissociation achieves a replacement of zinc lost in the body fluids, such as in the urine, after thermal or other trauma. Although both zinc sulfadiazine and silver sulfadiazine each effectively controls infection and enhances healing in burn wounds, the combination of zinc sulfadiazine and silver sulfadiazine, particularly in a single medicament, possesses enhanced efficacy.
Claims18
A composition useful for treating burns consisting essentially of an admixture of silver sulfadiazine and zinc sulfadiazine dispersed as finely divided particles in a water-dispersible hydrophilic carrier, said admixture being present in said composition in an amount to about 10% by weight of said composition and said silver sulfadiazine and said zinc sulfadiazine being present in said composition in an amount of at least 0.1% by weight and 1.0% by weight, respectively, based on said composition.
A composition useful for treating burns consisting essentially of 0-25% by weight petrolatum, 7-45% by weight of a long chain fatty alcohol having a carbon atom content in the range C.sub.16 -C.sub.22, an admixture consisting essentially of finely divided silver sulfadiazine and zinc sulfadiazine to about 10% by weight, 4-16% by weight of a non-ionic emusifying agent, 7-40% by weight of a humectant selected from the group consisting of propylene glycol, sorbitol and glycerine, 0-15% by weight of an emollient and an amount of water, when required, sufficient to bring the total of the percentages of the above-identified components to 100%, said silver sulfadiazine and said zinc sulfadiazine of said admixture being present in said composition in an amount of at least 0.1% by weight and 1.0% by weight, respectively, based on said composition.
A composition useful for treating burns consisting essentially of 0.1-10% by weight solid particleform zinc sulfadiazine dispersed in a physiologically acceptable carrier.
A composition useful for treating burns consisting essentially of 0-25% by weight petrolatum, 7-45% by weight of a long chain fatty alcohol having a carbon content in the range C.sub.16 -C.sub.22, 0.1-10% by weight finely divided zinc sulfadiazine, 4-16% by weight of a non-ionic emulsifying agent, 7-40% by weight of a humectant selected from a group consisting of propylene glycol, sorbitol and glycerine, 0-15% by weight of an emollient and an amount of water, when required, sufficient to bring the total of the percentages of the above-identified components to 100%.
A method of treating burns in animal or man which comprises topically applying an effective antibacterial amount of zinc sulfadiazine to the affected surface.
A method of treating burns in animal or man which comprises separately topically applying an effective antibacterial amount of silver sulfadiazine and an effective antibacterial amount of zinc sulfadiazine to the affected surface.
Zinc sulfadiazine.
Dependencies are inferred from the claim text.