Composition and method for treatment of heart and circulatory ailments
AssigneeCiba-Geigy Corporation
InventorsKnut A. Jaeggi, Herbert Schroter, Franz Ostermayer
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Abstract
1-Phenoxy-2-hydroxy-3-amino-propanes of the formula I ##STR1## wherein R.sub.1 is a sugar residue and R.sub.2 is isopropyl, tert.-butyl or .alpha.-methyl-phenethyl optionally substituted in the phenyl part, and salts thereof are useful as positively inotropic agents, especially in the treatment of insufficiency of the cardiac muscle.
Claims4
A pharmaceutical composition useful as positively inotropic agent in the treatment of insufficiency of the cardiac muscle, comprising a corresponding therapeutically effective amount of a sugar compound of the formula I ##STR5## wherein R.sub.1 represents 1-glucopyranosidyl, 2,3,4,6-tetra-O-alkanoylated 1-glucopyranosidyl, the alkanoyl radical of which having up to four carbon atoms, or 2,4O,O -alkylidene substituted 1-glucopyranosidyl, the alkylidene radical of which having up to four carbon atoms, or 2,4-O-benzylidene substituted 1-glucopyranosidyl, R.sub.2 is isopropyl, tert.-butyl, .alpha.-methyl-phenethyl or 1-methyl-3-phenyl-propyl, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically usable excipient.
A method for the treatment of insufficiency of the cardiac muscle in a warm-blooded animal, which comprises administering to said animal enterally or parenterally a therapeutically effective amount of the composition claimed in claim 6.
Dependencies are inferred from the claim text.