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US 4,049,793 AGranted
Preparations for local treatment of acne vulgaris
OwnerHelmut Sticklinventor
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Abstract
The invention provides a novel preparation, preferably in ointment form, for local treatment of acne vulgaris, methods for production of the same and method for treatment of acne vulgaris therewith.
Claims11
A preparation for the local treatment of acne vulgaris comprising, in combination with a suitable vehicle, about 20-40% by weight of an active substance obtained by:
- a. growing Coryne bacteria acnes in a liquid growth medium under anaerobic conditions at pH 5.5 to 6.0 with incubation at 35.degree. C. for up to 9-16 days until the multiplication peak has passed,
- b. separating the acne inhibitor acnecine discharged by the growth of said bacteria into said growth medium as an acnecine-containing liquid from said bacteria and other accompanying substances in said growth medium, and
- c. concentrating said acnecine-containing liquid into an acnecine concentrate comprising said active substance.
A method for the production of preparations for the local treatment of acne vulgaris, particularly in the form of ointments and face lotions comprising the steps of:
- a. growing Coryne bacteria acnes in a liquid growth medium under anaerobic conditions at pH 5.5 to 6.0 with incubation at 35.degree. C. for up to 9-16 days until the multiplication peak has passed,
- b. separating the acne inhibitor acnecine discharged by the growth of said bacteria into said growth medium, as anacnecine-containing liquid, from said bacteria and other accompanying substances in said growth medium,
- c. concentrating said acnecine-containing liquid into an acnecine concentrate, and
- d. incorporating about 20-40% by weight of said acnecine concentrate in a water-in-oil emulsion by adding suitable emulsifiers.
1 more element
Dependencies are inferred from the claim text.