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US 4,049,697 AGranted
(DL)-13-Substituted sulfinyl-prostaglandin-like compounds and methods of making
AssigneeSyntex (U.S.A.) Inc.
InventorsKarl G. Untch, Gilbert J. Stork
Life of this patent
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Abstract
(dl)-13-Substituted sulfinyl-prostaglandin-like [(dl)-2.alpha.-substituted-3.beta.-(1.alpha.-substituted sulfinyl-trans-2-alkenyl)-1-oxygenated cyclopentane and (dl)-2.alpha.-substituted-3.beta.-(1.alpha.-substituted sulfinyl-trans-2-alkenyl)-4-oxygenated-1-oxygenated cyclopentane] compounds exhibit prostaglandin-like biological properties and are also useful intermediates in the preparation of known prostaglandins.
Claims3
The (dl) compounds of the formulas:
- ##STR17## wherein R.sup.2 is hydrogen or hydroxyl;
- ##STR18## in which R.sup.3 is hydrogen or alkyl containing from one through three carbon atoms, and m is a whole integer from two through eight;
- ##STR19## wherein R.sup.7 is alkyl containing from one through six carbon atoms, cycloalkyl containing from five through seven carbon atoms, chloromethyl, trichloromethyl, trifluoromethyl, chlorodifluoromethyl, dichlorofluoromethyl, .beta.-chloroethyl, .alpha.-chloroethyl, or .alpha.-chloro-.beta.-trichloroethyl, and m is defined as above;
- and the wavy line (.xi.) represents the .alpha. or .beta. configuration or mixtures thereof;
- and the non-toxic, pharmaceutically acceptable salts of the compounds of Formulas (A) and (B) when R.sup.3 is hydrogen.
2 more elements
Dependencies are inferred from the claim text.