Stabilized blood separating composition
AssigneeCorning Glass Works
InventorAnthony R. Zine, Jr.
Life of this patent
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Abstract
Gel-like composition useful for separating and partitioning whole blood into serum and clot portions. The composition has a specific gravity between that of the serum and clot portions such that, when centrifuged in the presence of whole blood, the composition forms a chemical and physical barrier between the serum and clot portions. The composition comprises, in combination, a silicone fluid, an inert siliceous filler dispersed therein, and a network former consisting of a polysiloxane-polyoxyalkyl copolymer which stabilizes the composition by minimizing and/or avoiding "wet out" of the siliceous filler with time. The composition has a viscosity within the range of about 200,000 to about 600,000 centistokes, preferably within the range of about 350,000 to about 450,000 centistokes.
Claims4
In a thixotropic composition useful as a chemical and physical barrier between serum and clot portions of separated blood, the composition comprising a gel-like material having a specific gravity within the range of about 1.030 to 1.090 and consisting of a dimethylsiloxane silicone fluid having an inert siliceous filler dispersed therein, the improvement which comprises the addition of a network former in a quantity sufficient to maintain the viscosity of the composition within the range of 200,000 to 600,000 centistokes for prolonged periods of time, the network former consisting of a polysiloxane-polyoxyalkyl copolymer represented by the following formual ##STR2## where the monomeric units are randomly distributed and Me represents --CH.sub.3 ;
- x represents a number between 80 and 120;
- y represents a number between 8 and 12;
- P represents a polyoxyalkyl side chain represented by the formula
- CH.sub.2 --CH.sub.2 --O).sub.m (CH.sub.2 --CH.sub.2 --CH.sub.2 --O).sub.n
- where the monomeric units are randomly distributed and
- m represents a number between 20 and 30;
- and
- n represents a number between 1 and 30.
Dependencies are inferred from the claim text.