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US 4,049,669 AGranted
Process for preparing 5-(alkoxy- and aminoethyl thio)methylthiazole compounds
AssigneeSmithKline Corporation
InventorsBing Lun Lam, Joseph James Lewis, Robert Lee Webb, George Robert Wellman
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Abstract
A process for preparing 5-(alkoxy- and aminoethylthio)methylthiazole compounds via displacement of the trisubstituted phosphonium group from 5-(trisubstituted phosphonium)methylthiazole compounds is disclosed.
Claims10
A process for preparing a compound of the formula:
- ##STR3## in which:
- R.sup.1 is hydrogen or lower alkyl;
- and
- R.sup.2 is methoxy, ethoxy, n-propoxy, n-butoxy, i-butoxy, t-butoxy or --SCH.sub.2 CH.sub.2 NH.sub.2 ;
- comprising reacting a compound of the formula:
- ##STR4## in which:
- R.sup.1 is defined as above;
- R.sup.3 is lower alkyl or phenyl;
- and
- X is halo,
- with a compound of the formula R.sup.2 --H where R.sup.2 is defined as above in an polar organic solvent and in the presence of a strong base.
8 more elements
Dependencies are inferred from the claim text.