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US 4,049,662 AGranted
4-Quinoline and isoquinoline substituted 2,6-diamino-1,4-dihydropyridine derivatives
AssigneeBayer Aktiengesellschaft
InventorsHorst Meyer, Friedrich Bossert, Wulf Vater, Kurt Stoepel
Life of this patent
Estimating the term…
Abstract
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2,6-diamino-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an amidine with either an aldehyde or an ylidenecyanoacetoacetic acid ester.
Claims5
A compound of the formula:
- ##STR29## wherein R is quinolyl or isoquinolyl unsubstituted or substituted by one or two members selected from the group consisting of lower alkyl, lower alkoxy and halogeno;
- and
- each of R.sup.1 and R.sup.2, taken independently of the other, is lower alkyl, lower alkoxy, lower alkoxy(lower alkoxy), alkenyloxy of 2 to 4 carbon atoms, alkynyloxy of 2 to 4 carbon atoms, amino, lower alkylamino or di(lower alkyl)amino.
Dependencies are inferred from the claim text.