Production of antibiotics neothramycin A and neothramycin B
AssigneeZaidan Hojin Biseibutsu Kagaku Kenkyu Kai
InventorsHamao Umezawa, Tomio Takeuchi, Masa Hamada, Shinichi Kondo, Masaaki Ishizuka, Hiroshi Naganawa
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Abstract
There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukema L-1210 cells in mice. They are produced by controlled fermentation of Streptomyces FERM-P 2452 (A.T.C.C. 31123).
Claims21
The process for producing the antibiotic neothramycin complex which comprises culturing a neothramycin-producing strain of Streptomyces having the identifying characteristics of A.T.C.C. 31123 under submerged aerobic conditions in a nutrient medium containing a carbon source and a nitrogenous nutrient until a substantial amount of neothramycin is produced by said organism in said nutrient medium.
The process for producing neothramycin A which comprises culturing a neothramycin A producing strain of Streptomyces having the identifying characteristics of A.T.C.C. 31123 under submerged aerobic conditions in a nutrient medium containing a carbon source and a nitrogenous nutrient until a substantial amount of neothramycin A is produced by said organism in said nutrient medium.
The process for producing neothramycin B which comprises culturing a neothramycin B-producing strain of Streptomyces having the identifying characteristics of A.T.C.C. 31123 under submerged aerobic conditions in a nutrient medium containing a carbon source and a nitrogenous nutrient until a substantial amount of neothramycin B produced by said organism in said nutrient medium.
The process of claim 25 in which the strain of Streptomyces is cultured in a nutrient medium at a temperature in the range of 25.degree. C. to 29.degree. C. with the pH from 6 to 8.
Dependencies are inferred from the claim text.