9-(3,5-Di-O-acyl-.beta.-D-arabinofuranosyl)adenine compounds and method for their production
AssigneeParke, Davis & Company
InventorDavid Clarkston Baker
Life of this patent
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Abstract
9-(3,5-Di-O-acyl-.beta.-D-arabinofuranosyl)adenine compounds and their production by reacting in each case a 9-(5-O-tri-substituted-silyl-2,3-di-O-acyl-.beta.-D-arabinofuranosyl)adeni ne compound with a tetraalkylammonium fluoride. The compounds are useful as antiviral agents. The compounds are stable and being lipophilic are adaptable to long-acting and depot injectable pharmaceutical formulation.
Claims8
9-(3,5-Di-O-acyl-.beta.-D-arabinofuranosyl)adenine compounds having the formula ##STR3## where R is an alkanoyl group having from 2 to 4 carbon atoms.
Method for the production of 9-(3,5-di-O-acyl-.beta.-D-arabinofuranosyl)adenine compounds having the formula ##STR4## where R is an alkanoyl group having from 2 to 4 carbon atoms, which comprises reacting a 5-silyl ether derivative represented by the formula ##STR5## with an equivalent quantity of a tetra(lower)alkylammonium fluoride where R is an alkanoyl group having from 2 to 4 carbon atoms, R.sup.1 is lower alkyl, and R.sup.2 and R.sup.3 represent lower alkyl or phenyl or together are tetramethylene.
Dependencies are inferred from the claim text.