Method of inhibiting myocardial ischemia in mammals using quaternary salts
AssigneeThe Regents of the University of Michigan
InventorBenedict R. Lucchesi
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Abstract
1-(N-isopropyl-N,N-dimethylamino)-3-(1-naphthoxy)propan-2-ol quaternary salts are useful cardiovascular agents as evidenced by their potent and long-acting anti-arrhythmic, anti-fibrillatory and myocardial ischemia-inhibitory activity. They, furthermore, lack the undesirable side-effects, e.g. .beta.-adrenergic receptor blocking and local anesthetic activity, characteristic of related prior art compounds.
Claims4
A method of inhibiting myocardial ischemia in mammals which comprises administering to mammals requiring inhibition of myocardial ischemia a therapeutically effective amount of a compound of the formula
- wherein X.sup.- is the anion of a pharmaceutically acceptable non-toxic
Dependencies are inferred from the claim text.