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AssigneeMedizinska Akademia
InventorsAngel Simeonov Galabov, Lubomir Mihaylov Shindarov, Georgi Nikolov Vassilev, Ragka Taneva Vassileva, Zlatka Petkova Dimcheva, Dushka Staneva Stoycheva, Emilia Hristova Velichkova
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A method of treating picorna viral infections, particularly of the picornaviruses, is provided which comprises treating the patient with an effective amount of a compound of the formula ##STR1## wherein R is hydrogen or methyl; and R' is lower alkyl, allyl, .beta.-hydroxyethyl, .beta.-aminoethyl, .omega.-aminohexyl, a fatty acid radical, methoxyphenyl, chlorophenyl, phenyl, benzyl, tolyl, hydroxyphenyl, carboxyphenyl, chinoyl, carboxyhydroxyphenyl, hydroxynitrophenyl, nitrophenyl, hydroxychlorophenyl, chloronitrophenyl, phenylthioureidohexyl, trimethylphenyl, methylchlorophenyl, pyridyl, acetylphenyl, acetylaminophenyl, dimethylaminophenyl, aminopyridyl, phenylthioureidopyridyl, phenylthioureidonaphtyl, aminonaphthyl, chlorophenylthioureidophenyl, furfuryl, dichlorophenyl or allylthioureidophenyl. The compound may be administered orally, preferably in dosages of from 40 to 200 mg per kilogram body weight.
A method of treating a picorna virus infection which comprises orally administering to a patient an anti-picorna virus effective amount of N-phenyl-N-4-hydroxy-phenylthiourea or N-phenyl-N-3-hydroxy-phenylthiourea.
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