Alkyl derivatives of 4,5-dehydro PGE.sub.1
AssigneeAmerican Home Products Corporation
InventorsNedumparambil A. Abraham, Jehan F. Bagli, Tibor Bogri
Life of this patent
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Abstract
15- And/or 16-alkyl derivatives of 9,15-dioxygenated prost-13-enoic, prosta-4,13-dienoic and prosta-5,13-dienoic acid, lower alkyl esters thereof and homologs thereof, as well as a process for preparing these derivatives are disclosed. The compounds possses hypotensive, antihypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. The compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.
Claims7
A compound of formula ##STR11## in which m is an integer from zero to two, n is an integer from two to five, X and Y together represent oxo, Z represents the radical cis-CH.sub.2 --CH.dbd.CH--, R.sup.1 is hydrogen or lower alkyl and R.sup.2, R.sup.3 and R.sup.4 each are hydrogen or lower alkyl with the provisos that at least one of R.sup.2, R.sup.3 or R.sup.4 is lower alkyl and at least one of R.sup.2, R.sup.3 or R.sup.4 is hydrogen.
A pharmaceutical composition comprising:
- a. A compound of formula ##STR12## in which m is an integer from zero to two, n is an integer from two to five, X and Y together represent oxo, Z represents the radical cis--CH.sub.2 --CH.dbd.CH--, R.sup.1 is hydrogen or lower alkyl and R.sup.2, R.sup.3 or R.sup.4 is lower alkyl and at least one of R.sup.2, R.sup.3 or R.sup.4 is hydrogen, and
- b. a pharmacologically acceptable carrier.
Dependencies are inferred from the claim text.