Treatment of helminth infections with substituted 1,2-bis(thioureido)benzene
AssigneeMay & Baker Limited
InventorsSamuel Sidney Berg, David Conwil Jenkins, Ronald Frederick Phillipson
Life of this patent
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Abstract
Benzene derivative of the formula: ##STR1## wherein R and R.sup.1 each represent an aliphatic hydrocarbon group optionally substituted by halogen or alkoxy, R.sup.2 and R.sup.3 each represent hydrogen or methyl, and R.sup.4 represents hydrogen, halogen, alkyl, alkanoylamino optionally substituted by cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonylamino, alkanoyl, benzyl or N-methylmethanesulphonylamino, possess anthelmintic and anti-viral activity. New compounds within that formula also possess fungicidal properties.
Claims15
A method for the treatment of helminth infections in man and domestic animals which comprises administering to man or a domestic animal infected with helminths an anthelmintically effective amount of at least one benzene derivative of the formula;
- ##STR8## wherein R and R.sup.1 each represent an aliphatic hydrocarbon group of 1 to 4 carbon atoms which is unsubstituted or substituted by halogen or alkoxy of 1 to 4 carbon atoms, R.sup.2 and R.sup.3 each represent hydrogen or methyl, and R.sup.4 represents hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkanoylamino of 1 to 4 carbon atoms which is unsubstituted or substituted by cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonylamino of 2 to 4 carbon atoms, alkanoyl of 2 to 4 carbon atoms, benzoyl or N-methylmethanesulphonylamino.
Medicated animal feedstuffs comprising an animal feedstuff and 0.001% to 3% by weight of said feedstuff of a benzene derivative of the formula:
- ##STR9## wherein R and R.sup.1 each represent an aliphatic hydrocarbon group of 1 to 4 carbon atoms which is unsubstituted or substituted by halogen or alkoxy of 1 to 4 carbon atoms, R.sup.2 and R.sup.3 each represent hydrogen or methyl, and R.sup.4 represents hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkanoylamino of 1 to 4 carbon atoms which is unsubstituted or substituted by cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonylamino or 2 to 4 carbon atoms, alkanoyl of 2 to 4 carbon atoms, benzoyl or N-methylmethanesulphonylamino.
A method for the treatment of helminth infections in man and domestic animals which comprises administering to man or a domestic animal infected with helminths an anthelmintically effective amount of at least one benzene derivative of the formula:
- ##STR10## wherein R and R.sup.1 each represent an aliphatic hydrocarbon of 1 to 4 carbon atoms which is unsubstituted or substituted by halogen or alkoxy of 1 to 4 carbon atoms, R.sup.2 and R.sup.3 each represent hydrogen or methyl, and R.sup.4 represents hydrogen, halogen or alkyl of 1 to 4 carbon atoms.
A method of controlling helminths in sheep which comprises the oral administration to sheep in need of such control an anthelmintically effective amount of a compound corresponding to the following formula:
- ##STR11##
Dependencies are inferred from the claim text.