Low toxicity method of inhibiting sickling of sickle erythrocytes
AssigneeThe United States of America as represented by the United States Energy Research and Development Administration
InventorsLester Packer, Edwin N. Bymun
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Abstract
A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.
Claims9
A method of inhibiting sickling of human sickle erythrocytes which comprises intermixing the erythrocytes with a water-soluble monofunctional imidoester having the general formula RC(.dbd.NH)OR' wherein R is an alkyl group of 1-8 carbon atoms and R' is an alkyl group of 1-4 carbon atoms in a amount effective to inhibit sickling and below the toxicity level of the imidoester.
Dependencies are inferred from the claim text.