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US 4,048,311 AGranted
7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins
AssigneeSmithKline Corporation
InventorDavid A. Berges
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Abstract
The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
Claims31
A compound of the formula ##STR9## in which:
- W is hydrogen or methoxy;
- each individual R.sup.1 is hydrogen or lower alkyl;
- n is one to ten;
- R.sup.2 is hydroxy, amino, lower alkylamino or di(lower)alkylamino;
- R.sup.3 is an acyl group of the formula:
- ##STR10## where:
- X is thienyl;
- dihydrophenyl;
- phenyl;
- phenyl monosubstituted with hydroxy, hydroxymethyl, formamido, ureido or carboxymethylamino;
- or 3-fluoro-4-hydroxyphenyl;
- and
- A is NH.sub.2, OH, COOH or SO.sub.3 H;
- or formyloxy when X is phenyl;
- or a non-toxic pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.