Topical steroid formulation in form of lotion or cream
AssigneeE. R. Squibb & Sons, Inc.
InventorsJames Ling Chen, Jean M. Battaglia
Life of this patent
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Abstract
Steroid formulations in the form of creams or lotions which are used as topical anti-inflammatory agents are provided wherein the steroid, such as 21-chloro-9.alpha.-fluoro-.DELTA..sup.4 -pregnene-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione 16,17-acetonide, is at least partially dissolved in a ricinoleate vehicle such as castor oil.
Claims25
A composition for topical application in the form of a cream or lotion, comprising at least one steroid wherein said steroid is selected from the group consisting of 21-chloro-9.alpha.-fluoro-.DELTA..sup.4 -pregnene-11.beta., 16.alpha.,17.alpha.-triol-3,20-dione 16,17-acetonide;
- 21-chloro-9-fluoro-2',3'-dihydro-11.beta.-hydroxy-5'-propylpregna-1,4-dien o[16.alpha.,17-b][1,4]-dioxin-3,20-dione:dichloro methane solvate (1:1);
- and 9.alpha.-fluoro-11.beta., 16.alpha.,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione 16,17-acetonide, a ricinoleate vehicle in which said steroid is at least partially soluble, an emulsifier-thickener comprising a polyethylene glycol ether of a fatty alcohol, an oleaginous material or emollient, a preservative and water.
Dependencies are inferred from the claim text.