Tripeptides, their esters and amides, and anti-ulcera activity thereof
AssigneeDr. L. Zambeletti S.p.A.
InventorsLuigi Molteni, Gian Piero Vercesi, Eraldo Antonini
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Abstract
This invention relates to aseries of tripeptides of the general formula: ##STR1## wherein R = -- H, COCH.sub.3, alkyl R.sub.1 = --oh, --nh.sub.2, --nh alkyl (C.sub.1 -C.sub.5) --O alkyl (C.sub.1 -C.sub.5) resulting from condensing of racemic, levorotatory and dextrorotatory phenylalanine and histidine and having an anti-ulcer activity.
Claims9
Tripeptides of the general formula:
- ##STR4## wherein R = -- H, COCH.sub.3, alkyl
- R.sub.1 = --oh, --nh.sub.2, --nh alkyl (C.sub.1 -C.sub.5) --O alkyl (C.sub.1 -C.sub.5)
- resulting from condensing of racemic, levorotatory and dextrorotatory phenylalanine and histidine.
N-acetyl-l-phenylalanyl-d-phenylalanyl-l-histidine methylester.
N-acetyl-l-phenylalanyl-d-phenylalanyl-l-histidineamide.
N-acetyl-dl-phenylalanyl-dl-phenylalanyl-dl-histidine methylester.
N-acetyl-l-phenylalanyl-l-phenylalanyl-l-histidine methylester.
N-acetyl-l-phenylalanyl-l-phenylalanyl-l-histidineamide.
N-acetyl-l-phenylalanyl-l-phenylalanyl-l-histidine.
N-acetyl-l-phenylalanyl-l-phenylalanyl-l-histidylmethylamide.
Dependencies are inferred from the claim text.