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US 4,048,229 AGranted
.alpha.-AMINOMETHYL-4-HYDROXY-3-METHYLSULFONYL BENZYL ALCOHOLS
AssigneeSmithKline Corporation
InventorsDonald F. Colella, Carl Kaiser
Life of this patent
Estimating the term…
Abstract
.alpha.-Aminomethyl-4-hydroxy-3-methylsulfonyl benzyl alcohols having .beta.-adrenergic antagonist activity are prepared generally from 4-benzyloxy-3-methylsulfonylacetophenone by, for example, bromination and treatment of the resulting .alpha.-bromo derivative with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove protective benzyl groups and reduce the ketone moiety.
Claims5
A chemical compound of the formula:
- ##STR3## or a pharmaceutically acceptable acid addition salt of said compound, wherein:
- R is straight or branched chain lower alkyl of from 1 to 6 carbon atoms, cycloalkyl or cycloalkylmethyl, the cycloalkyl moiety having from 3 to 6 carbon atoms, XC.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3), XC.sub.6 H.sub.4 CH.sub.2 C(CH.sub.3).sub.2 or XC.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH(CH.sub.3);
- and
- X is hydrogen, hydroxy or methoxy.
1 more element
Dependencies are inferred from the claim text.