Certain 2-substituted 4-phenylquinoline-4-ols
AssigneeJohn Wyeth & Brother Limited
InventorRobin Michael Black
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Abstract
The invention relates to quinoline derivatives of the formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts of those compounds capable of forming acid addition salts. In formula (I), R.sup.1 and R.sup.2 which may be the same of different each represent hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, R.sup.3 and R.sup.4 which may be the same or different each represent lower alkyl and X represents hydroxy, halogen, hydrazino, or a radical of formula -NR.sup.5 R.sup.6 where R.sup.5 and R.sup.6 which may be the same or different each represent hydrogen or lower alkyl or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are both attached represent a saturated heterocyclic ring containing 5 to 7 ring atoms. The compounds possess hypotensive activity.
Claims7
A 4-phenylquinolin-4-ol selected from the group consisting of compounds having the formula (I) ##STR6## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 and R.sup.2, which may be the same or different, each represent hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, R.sup.3 and R.sup.4, which may be the same or different, each represent lower alkyl and X represents hydrazino, amino, (lower)alkylamino, or di(lower)alkylamino, with the proviso that R.sup.3 and R.sup.4 cannot be groups which give rise to steric hindrance.
Dependencies are inferred from the claim text.