Tetrahydroquinoline derivatives
AssigneeJohn Wyeth & Brother Limited
InventorsAdrian Charles Ward Curran, Roger Crossley, David George Hill
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Abstract
The invention provides 5,6,7,8-tetrahydroquinoline derivatives which are substituted at the 8-position by the group NHCSNHR.sup.5 where R.sup.5 is lower alkanoyl or aroyl. These compounds are intermediates for corresponding compounds where R.sup.5 is hydrogen, such compounds being anti-ulcer agents. This application is a continuation-in-part of our copending U.S. application Ser. No. 554,259 filed Feb. 28, 1975, now U.S. Pat. No. 3,991,065.
Claims4
A compound of formula I ##STR3## and pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and represent hydrogen, or a lower alkyl of 1-6 carbon atoms, R.sup.4 represents hydrogen or substitution at the 5, 6 or 7-position by lower alkyl of 1-6 carbon atoms, R.sup.5 is lower alkanol of 2-7 carbon atoms, benzoyl or halobenzoyl with the proviso that when any two of R.sup.1, R.sup.2 and R.sup.3 are lower alkyl and are on adjacent carbon atoms then they are selected from normal and secondary alkyl groups.
Dependencies are inferred from the claim text.