7-[.alpha.-(Benzimidazol-2-ylcarbonylamino)-arylacetamido]ephalosporins
AssigneeEli Lilly and Company
InventorsWilliam H. W. Lunn, Edward V. Mason
Life of this patent
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Abstract
Cephalosporin antibiotics of the formula ##STR1## in which, for example, R is phenyl, hydroxyphenyl, halophenyl, thienyl, or furyl; R.sub.1 is hydrogen, carbamoyloxy, acetoxy, a lower alkyl substituted 1H-tetrazol-5-ylthio or 1,3,4-thiadiazol-5-ylthio group; and R.sub.2 is hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, chloro, bromo, or fluoro; are highly active broad spectrum antibiotics especially useful in the treatment of infections attributable to the gram-negative microorganisms.
Claims16
A compound of the formula ##STR26## in which R is phenyl, monohydroxyphenyl, dihydroxyphenyl, monohalophenyl, monohydroxy substituted monohalophenyl, thienyl, or furyl;
- R.sub.1 is ##STR27## in which, in any of the above, X is .dbd.CH-- or .dbd.N--, and R.sub.3 is hydrogen or C.sub.1 -C.sub.4 alkyl;
- R.sub.2 is hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, chloro, bromo, or fluoro;
- and R.sub.5 is hydrogen, indanyl, phthalidyl, an acyloxymethyl group of the formula ##STR28## in which Y is C.sub.1 -C.sub.4 alkyl or phenyl, or, when R.sub.5 is hydrogen, the pharmaceutically acceptable non-toxic salts thereof.
Dependencies are inferred from the claim text.