Tetrahydropyranyl ethers of estrogens
AssigneeFarmila Farmaceutici
InventorsPietro de Ruggieri, Orazio Sighinolfi
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Abstract
Tetrahydropyranyl ethers of estrogens have interesting properties in the cure of climateric and menopausal disturbances, with an excellent dissociation index between their selective effect on the vagina and their very small or zero effect on the endometrium.
Claims14
Process for preparing a compound of the formula ##STR4## which comprises debenzylating by catalytic hydrogenation the corresponding 3-benzyloxy-16.alpha.- or 16.beta.-, 17.beta.-bis-(2'-tetrahydropyranyloxy) compound in an organic solvent.
A compound comprising of 3-benzyloxy-17.beta.-(2'-tetrahydropyranyloxy)-estra-1,3,5(10)-trien-16-on e.
A compound comprising of 3-methoxy-17.beta.-(2'-tetrahydropyranyloxy)-estra-1,3,5(10)-trien-16-one.
A compound comprising of 17.beta.-(2'-tetrahydropyranyloxy)-estra-1,3,5(10)-trien-16-one.
A compound comprising of 3,17.beta.-bis-(2'-tetrahydropyranoloxy)-estra-1,3,5(10-trien-16-one.
A compound comprising of 3-benzyloxy-17.beta.-(2'-tetrahydropyranyloxy)-estra-1,3,5 (10)-trien-16.beta.-ol.
A compound comprising of 3-methoxy-17.beta.-(2'-tetrahydropyranyloxy)-estra-1,3,5 (10)-trien-16.beta.-ol.
A compound comprising of 3-benzyloxy-17.beta.-(2'-tetrahydropyranyloxy)-estra-1,3,5 (10)-trien-16.alpha.-ol.
A compound comprising of 3-methoxy-17.beta.-(2'-tetrahydropyranyloxy)-estra-1,3,5 (10)-trien-16.alpha.-ol.
A compound comprising of 3-benzyloxy-16.beta.,17.beta.-bis-(2'-tetrahydropyranyloxy)-estra-1,3,5(10 )-triene.
A compound comprising of 3-methoxy-16.beta.,17.beta.-bis-(2'-tetrahydropyranyloxy)-estra-1,3,5(10)- triene.
A compound comprising of 16.beta.,17.beta.-bis-(2'-tetrahydropyranyloxy)-estra-1,3,5(10)-trien-3-ol .
A compound comprising of 3-methoxy-16.alpha.,17.beta.-bis-(2'-tetrahydropyranyloxy)-estra-1,3,5(10) -triene.
Dependencies are inferred from the claim text.