Biocompatible hemoperfusion system
OwnerWilliam T. Clark, IIIinventor
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Abstract
A biocompatible hemoperfusion system employing a polymer-coated detoxicant composition comprising a solid detoxicant having a semipermeable polymer coating which substantially retains free heparin is disclosed. The semipermeable polymer coating has an effective pore size permitting waste metabolites and toxins to diffuse therethrough. A cartridge for extracorporeal hemoperfusion comprising a plurality of particles is provided.
Claims25
A polymer-coated detoxicant composition adapted for reaction in an extracorporeal shunt with waste metabolites and toxins found in blood comprising a solid detoxicant having a semipermeable polymer coating:
- having an effective coating pore size permitting waste metabolites and toxins to diffuse therethrough;
- having free heparin therein;
- having an effective coating pore size permitting substantial retention of the free heparin by the polymer membrane;
- being insoluble in blood.
A process for extracorporeal hemoperfusion comprising the step of passing the blood through a polymer-coated detoxicant composition adapted for reaction in an extracorporeal shunt with waste metabolites and toxins found in blood and which composition comprises a solid detoxicant having a semipermeable polymer coating:
- having an effective coating pore size permitting waste metabolites and toxins to diffuse therethrough;
- having free heparin therein;
- having an effective coating pore size permitting substantial retention of the free heparin by the polymer coating;
- being insoluble in blood.
A process for extracorporeal hemoperfusion comprising the step of passing blood through a detoxicant composition of particles having a semipermeable polymer coating:
- having an effective coating pore size permitting waste metabolites and toxins to diffuse therethrough;
- having free heparin therein;
- having an effective coating pore size permitting substantial retention of the free heparin by the polymer membrane;
- being insoluble in blood, the particles of which are maintained under movement-inhibiting compression.
A cartridge for extracorporeal hemoperfusion comprising a plurality of particles of solid detoxicant having a semipermeable polymer coating:
- having an effective coating pore size permitting waste metabolites and toxins to diffuse therethrough;
- having free heparin therein;
- having an effective coating pore size permitting substantial retention of the free heparin by the polymer membrane;
- being insoluble in blood held under movement-inhibiting compression within a blood-permeable container.
A cartridge for extracorporeal hemoperfusion comprising:
- A. a plurality of particles of solid detoxicant having a semipermeable polymer coating:
- having an effective coating pore size permitting waste metabolites and toxins to diffuse therethrough;
- having free heparin therein;
- having an effective coating pore size permitting substantial retention of the free heparin by the polymer membrane;
- being insoluble in blood held under movement inhibiting compression within:
- B. a knitted nylon mesh tube surrounding the particles wherein:
- 1. the tube is closed at its upper and lower ends;
- 2. the openings in the mesh are larger than blood cells but smaller than the particles of solid detoxicant;
- 3. the tube is outwardly stretched in all directions and is in contact with the particles of solid detoxicant holding them under movement-inhibiting compression.
A process for extracorporeal hemoperfusion comprising the step of passing the blood through a cartridge comprising:
- A. a plurality of particles of solid detoxicant composition comprising a solid detoxicant having a semipermeable polymer coating:
- having an effective pore size permitting waste metabolities and toxins to diffuse therethrough;
- having free heparin therein;
- having an effective pore size permitting substantial retention of the free heparin by the polymer coating;
- being insoluble in blood, and said solid detoxicant composition is held under movement inhibiting compression within:
- B. a knitted nylon mesh tube surrounding the particles wherein:
- 1. the tube is closed at its upper and lower ends;
- 2. the openings in the mesh are larger than blood cells but smaller than the particles of solid detoxicant;
- 3. the tube is outwardly stretched in all directions and is in contact with the particles of solid detoxicant holding them under movement-inhibiting compression.
A process for extracorporeal hemoperfusion comprising sequentially:
- I. perfusing a cartridge containing particulate detoxicant composition with a biocompatible washing perfusate,
- Ii. and then passing blood through the cartridge at a rate less than the rate at which the biocompatible washing perfusate is perfused through the cartridge.
A process for extracorporeal hemoperfusion comprising sequentially:
- I. Perfusing a cartridge containing particulate detoxicant composition wherein the cartridge comprises:
- A. a plurality of particles of solid detoxicant held under movement inhibiting compression within:
- B. a knitted nylon mesh tube surrounding the particles wherein:
- 1. the tube is closed at its upper and lower ends;
- 2. the openings in the mesh are larger than blood cells but smaller than the particles of solid detoxicant;
- 3. the tube is outwardly stretched in all directions and is in contact with the particles of solid detoxicant holding them under movement-inhibiting compression, and wherein the particulate detoxicant composition comprises a solid detoxicant having a semi-permeable polymer coating, having an effective coating pore size permitting waste metabolities and toxins to diffuse therethrough;
- having free heparin therein;
- having an effective coating pore size permitting retention of the free heparin by the polymer membrane;
- being insoluble in blood;
- Ii. and then passing blood through the cartridge at a rate less than the rate at which the biocompatible washing perfusate is perfused through the cartridge.
Dependencies are inferred from the claim text.