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AssigneeAstra Nutrition AB
InventorsBo Erik Hallgren, Gunnel Anna Maria Stallberg
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Pharmaceutical preparations containing alkyl and alkenyl glycerol ethers substituted in the side chain and esters thereof having the general formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different in each is selected from the group consisting of hydrogen and aliphatic acyl groups of at most 24 carbon atoms, one of R.sup.3 and R.sup.4 being hydrogen and the other being selected from the group consisting of straight, branched, saturated and unsaturated alkoxy groups of at most seven carbon atoms, and R.sup.5 is selected from the group consisting of straight, branched, alkyl and alkenyl groups of 4-21 carbon atoms. The compounds are useful as antibiotics in the treatment of infectious diseases and for inhibiting the growth of tumors.
A pharmaceutical preparation containing as an active ingredient at least one glycerol ether of the formula ##STR20## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from the group consisting of hydrogen and aliphatic acyl groups of at most 24 carbon atoms, one of R.sup.3 and R.sup.4 being hydrogen and the other being selected from the group consisting of straight, branched, saturated and unsaturated alkoxy groups containing at most 7 carbon atoms, R.sup.5 is selected from the group consisting of straight, branched, alkyl and alkenyl groups of 4 to 21 carbon atoms, in association with a pharmaceutically acceptable carrier, said active ingredient being present in an amount of at least 5% by weight, effective to exhibit antibacterial or cytostatic activity.
A method for treating infectious bacterial diseases comprising the administration to a host having infectious diseases of an effective amount of at least one compound of the formula ##STR22## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from the group consisting of hydrogen and aliphatic acyl groups of at most 24 carbon atoms, one of R.sup.3 and R.sup.4 is hydrogen and the other is selected from the group consisting of straight, branched, saturated and unsaturated alkoxy groups of at most 7 carbon atoms, and R.sup.5 is selected from the group consisting of straight and branched alkyl and alkenyl groups of 4 to 21 carbon atoms.
A method for inhibiting the growth of tumors comprising administration to a host having tumors of an effective amount of at least one compound of the formula ##STR23## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from the group consisting of hydrogen and aliphatic acyl groups of at most 24 carbon atoms, one of R.sup.3 and R.sup.4 is hydrogen and the other is selected from the group consisting of straight, branched, saturated, and unsaturated alkoxy groups of at most 7 carbon atoms and R.sup.5 is selected from the group consisting of straight and branched alkyl and alkenyl groups of 4 to 21 carbon atoms.
A method for inhibiting the growth of tumors comprising administration to a host having tumors of a therapeutically effective amount of at least one compound of the formula ##STR24## wherein R.sup.1 and R.sup.2 are hydrogen, R.sup.3 is methoxy, R.sup.4 is hydrogen and R.sup.5 is selected from the group consisting of straight, branched, saturated and mono- and polyunsaturated groups of 4 to 21 carbon atoms.
A method of antibiotic treatment of bacteria selected from the group consisting of Corynebacterium hofmannii, Diplococcus pneumoniae, Staphylococcus pyogenes (A), Staphylococcus pyogenes (H Oxford), Streptococcus pyogenes and Streptococcus viridans comprising administering to a host having said bacteria an effective amount of a compound of the formula ##STR25## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from the group consisting of hydrogen and aliphatic acyl groups of at most 24 carbon atoms, one of R.sup.3 and R.sup.4 being hydrogen and the other being selected from the group consisting of straight, branched, saturated and unsaturated alkoxy groups of at most 7 carbon atoms, and R.sup.5 is selected from the group consisting of straight, branched, alkyl and alkenyl groups of 4 to 21 carbon atoms.
A method for inhibiting the growth of carcinoma comprising administering to a host having said carcinoma an effective amount of a compound of the formula ##STR26## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from the group consisting of hydrogen and aliphatic acyl groups of at most 24 carbon atoms, one of R.sup.3 and R.sup.4 being hydrogen and the other being selected from the group consisting of straight, branched, saturated and unsaturated alkoxy groups of at most 7 carbon atoms, and R.sup.5 is selected from the group consisting of straight, branched, alkyl and alkenyl groups of 4 to 21 carbon atoms.
A method for inhibiting the growth of induced tumors comprising administering to a host having tumors an effective amount of a compound of the formula ##STR27## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from the group consisting of hydrogen and aliphatic acyl groups of at most 24 carbon atoms, one of R.sup.3 and R.sup.4 being hydrogen and the other being selected from the group consisting of straight, branched, saturated and unsaturated alkoxy groups of at most 7 carbon atoms, and R.sup.5 is selected from the group consisting of straight, branched, alkyl and alkenyl groups of 4 to 21 carbon atoms.
A method for inhibiting the growth of induced carcinoma comprising administering to a host having said carcinoma an effective amount of a compound of the formula ##STR28## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from the group consisting of hydrogen and aliphatic acyl groups of at most 24 carbon atoms, one of R.sup.3 and R.sup.4 being hydrogen and the other being selected from the group consisting of straight, branched, saturated and unsaturated alkoxy groups of at most 7 carbon atoms, and R.sup.5 is selected from the group consisting of straight, branched, alkyl and alkenyl groups of 4 to 21 carbon atoms.
A method for inhibiting the growth of HeLa cells comprising subjecting said cells to an effective amount of a compound of the formula ##STR29## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from the group consisting of hydrogen and aliphatic acyl groups of at most 24 carbon atoms, one of R.sup.3 and R.sup.4 being hydrogen and the other being selected from the group consisting of straight, branched, saturated and unsaturated alkoxy groups of at most 7 carbon atoms, and R.sup.5 is selected from the group consisting of straight, branched, alkyl and alkenyl groups of 4 to 21 carbon atoms.
Dependencies are inferred from the claim text.