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US 4,046,907 AGranted
Imidazole alkylaminoethylene compounds
AssigneeSmith Kline & French Laboratories Limited
InventorsGraham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
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Abstract
The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[2-((4-methyl-5-imidazolyl)methylthio)-ethylamino] ethylene.
Claims10
A compound of the formula:
- ##STR8## wherein X and Y, which may be the same or different, are hydrogen, nitro, cyano or SO.sub.2 Ar but are not both hydrogen;
- R.sup.1 is Het-(CH.sub.2).sub.m Z(CH.sub.2).sub.n ;
- R is hydrogen, lower alkyl or, being the same or different from R.sub.1, Het-(CH.sub.2).sub.m Z(CH.sub.2).sub.n ;
- Z is sulphur or methylene;
- m is 0, 1 or 2 and n is 2 or 3 provided that the sum of m and n is 3 or 4;
- Het is an imidazole ring which ring is attached at a ring carbon and which ring is optionally substituted by lower alkyl or halogen;
- and Ar is an aryl group such as phenyl optionally substituted by halogen or methyl or a pharmaceutically acceptable acid addition salt thereof.
4 more elements
Dependencies are inferred from the claim text.