Hypolipemiant composition and method using thiazole-5-methanols

#Zubarovskii et al [Chem. Ab., Vol 58 (1963), p. 2,525b] describes the preparation of 2-methyl-thiazole-5-methanol by reaction of ethyl 2-methyl-thiazole-5-carboxylate with lithium aluminum hydride but does not describe any pharmacological properties therefor.

#It is an object of the invention to provide the novel thiazole derivatives of formula I and a process for their preparation.

#It is another object of the invention to provide novel hypolipemiant and vasodilatatory compositions.

#In the following examples there are described several preferred embodiments to illustrate the invention. However, it should be understood that the invention is not intended to be limited to the specific embodiments.

#Step a: methyl 2-ethyl-thiazole-5-carboxylate

#A solution of diazomethane in methylene chloride was added to a suspension of 10.45 g of 2-ethyl-thiazole-5-carboxylic acid in 30 ml of methylene chloride until efferversence stopped and the methylene chloride was distilled. The oily residue was chromatographed over silica and was eluted with a 1:1 mixture of benzene-ethyl acetate to obtain 11.3 g of methyl 2-ethyl-thiazole-5-carboxylate.