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US 4,046,889 AGranted
Azetidine-2-carboxylic acid derivatives
AssigneeE. R. Squibb & Sons, Inc.
InventorsMiguel Angel Ondetti, David W. Cushman
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Abstract
New proline derivatives and related compounds which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Claims23
A compound of the formula ##STR14## wherein R is hydroxy, amino or lower alkoxy;
- R.sub.1 and R.sub.4 each is hydrogen, lower alkyl or phenyl-lower alkyl;
- R.sub.2 is hydrogen or R.sub.5 --CO;
- R.sub.3 is hydrogen, hydroxy or lower alkyl;
- R.sub.5 is lower alkyl, phenyl or phenyl-lower alkyl;
- m is 1;
- n is 0, 1 or 2.
- and basic salts thereof.
4 more elements
Dependencies are inferred from the claim text.