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US 4,046,886 AGranted
Dermatological compositions
AssigneeThe Procter & Gamble Company
InventorDonald Edward Smith
Life of this patent
Estimating the term…
Abstract
Compositions for enhancing the penetration of pharmacologically active agents through skin comprising a sugar ester in combination with a sulfoxide or phosphine oxide.
Claims5
A composition adapted to topical application to animal tissue comprising:
- (1) a safe and effective amount of a pharmacologically active agent;
- (2) at least about 0.1% by weight of a sugar ester wherein said sugar ester is a member selected from the group consisting of sucrose monooctanoate, sucrose monodecanoate, sucrose monolaurate, sucrose monomyristate, sucrose monopalmitate, sucrose monostearate, sucrose monooleate, and sucrose dioleate;
- and (3) at least about 0.1% by weight of a phosphine oxide wherein said phosphine oxide is a member selected from the group consisting of octyl dimethyl phosphine oxide, nonyl dimethyl phosphine oxide, decyl dimethyl phosphine oxide, undecyl dimethyl phosphine oxide, dodecyl dimethyl phosphine oxide, 2-hydroxydecyl dimethyl phosphine oxide, 2-hydroxyundecyl dimethyl phosphine oxide and 2-hydroxydodecyl dimethyl phosphine oxide.
Dependencies are inferred from the claim text.