A method for the treatment of hypertension in mammals comprises administering to said mammal suffering from hypertension an effective dose of a water soluble carotenoid.
Drawings
Claims6
A method for the treatment of hypertension in mammals which comprises administering to said mammal suffering from hypertension an antihypertensively effective dose of a water soluble carotenoid.
6 Sep 1994Estimated · howhidePre-1995 term; greater of 17 years from grant or 20 years from filing when eligible. Maintenance-fee lapses, terminal disclaimers and statutory extensions have not been checked. The continuity chain may be incomplete; this is not an enforceability determination.
#A more complete appreciation of the invention and many of the attendant advantages thereof will be readily attained as the same becomes better understood by reference to the following detailed description when considered in connection with the accompanying drawing, wherein:
#THE FIGURE shows the results of crocetin treatment on the blood pressure in SHR rats.
Detailed description933 words
#Hypertension, which is commonly known as high blood pressure, is a very common disease. Another related, very common disease, atherosclerosis, has been successfully treated by applicant using the water-soluble carotenoids used in this application (see U.S. Pat. No. 3,853,993). While there does appear to be a link between the two conditions (for example, it has been reported that hypertension was present in about 70% of deaths due to atherosclerotic heart disease and coronary sclerosis was found in 90% of the hearts of people dying with hypertension -- Moriyama, I. M. et al., "Cardiovascular Diseases in the United States", Harvard Press 1971), they are each a unique and separate disease.
#For example, atherosclerosis is usually diagnosed through high blood lipid levels (cholesterol and triglycerides) while hypertension is diagnosed by direct measurement of blood pressure. Moreover, the drugs used to treat one disease are in general not used to treat the other.
#It has been noted that the lipid contents of various arteries are related to blood pressure [Paterson, J. C. et al., Canad. Med. J., 82, 65 (1960)] and that some antihypertensive drugs produce a parallel fall in serum cholesterol [Baker, A. B. et al., Circulation, 39, 701 (1969)]. However, in pharmaceutical science, the diseases are treated differently, and as two separate conditions since there is no necessary relationship between an antiatherosclerosis drug and an antihypertensive drug. In other words, from the fact that a drug is effective against one disease, nothing can be concluded concerning its likely effectiveness against the other.