Antiviral compositions

#This invention relates to novel topical antiviral compositions containing a complex-former for bivalent cations and a 5'-triphosphate of a nucleoside or deoxyribonucleoside, as well as to a method of treating topical virus infections therewith.

#More particularly, the present invention relates to novel antiviral compositions which are especially effective against the viruses of the family of picornaviridae, such as rhinoviruses, enteroviruses and caliciviruses, consisting of one or more complexing agents for bivalent cations and one or more nucleoside or deoxynucleoside triphosphates, optionally in combination with another active ingredient, for instance, an agent which constricts swollen mucous membranes, such as 2-(5,6,7,8-tetrahydro-1-naphthylamino)-1-imidazoline hydrochloride, or with detergents, preferably in the form of a neutral solution.

#The novel, stable antiviral compositions of the present invention are prepared by simply uniformly distributing one or more of the complex-formers for bivalent cations and one or more of the nucleoside or deoxynucleoside triphosphates, and optionally also another active ingredient, in a suitable inert carrier; for instance, by dissolving the ingredients in water, ethanol or ethanol/water, or by uniformly admixing them with a powder such as talcum, or by blending them into an ointment base.

#The solution was compounded from the following ingredients:

#______________________________________ Adenosine triphosphate (sodium salt) 5.0 parts Pyrophosphate (sodium salt) 100.0 " 2-(5,6,7,8-Tetrahydro-1-naphthyl- amino)-2-imidazoline hydrochloride 10.0 " Benzalkonium chloride 10.0 " Sodium dihydrogen phosphate 10.0 " Disodium hydrogen phosphate 20.0 " Tylose 10.0 " Distilled water q.s.ad 10,000.0 " by vol. ______________________________________

#The adenosine triphosphate, the pyrophosphate, the benzalkonium chloride and the tylose were dissolved in a sufficient amount of distilled water, the buffer substances were added, and the resulting solution was diluted with distilled water to the indicated volume.