Phosphonates containing protected ketone group
AssigneeImperial Chemical Industries PLC
InventorsRobert Foster, Roger Edwin Preston, Graham Ernest Robinson
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Abstract
The disclosure relates to novel protected ketone derivatives, for example dimethyl 3-(3-chlorophenoxy)-2-semicarbazonopropylphosphonate, for use as intermediates in the synthesis of known prostaglandin analogues, and to a process for their manufacture.
Claims4
A protected ketone derivative of the formula (R.sup.1 O).sub.2.PO.CH.sub.2.CR.sup.3.CH.sub.2 OR.sup.2, wherein R.sup.1 is C.sub.1-6 -alkyl, R.sup.2 is 3-chlorophenyl or 3-trifluoromethylphenyl and R.sup.3 is semicarbazono, thiosemicarbazono, oximino, C.sub.1-6 - alkyloxyimino, hydrazono, C.sub.1-6 -alkylhydrazono, phenylhydrazono, or phenylhydrazono substituted in the phenyl part with one or more substituents selected from halogen, C.sub.1-3 -alkyl or alkoxy, or nitro.
Dimethyl 3-(3-chlorophenoxy)-2-semicarbazonopropylphosphonate.
Dimethyl 3-(3-chlorophenoxy)-2-oximinopropylphosphonate or dimethyl 3-(3-chlorophenoxy)-2-methoxyiminopropylphosphonate.
Dependencies are inferred from the claim text.