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US 4,046,801 AGranted
13-Cis prostaglandin derivatives
AssigneeSyntex (U.S.A.) Inc.
InventorsArthur F. Kluge, Karl G. Untch, John H. Fried
Life of this patent
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Abstract
13-Cis prostaglandin derivatives; cis-octenol ether copper.sup.(I) lithium reagents and methods of making such reagents and using the reagents to prepare the 13-cis prostaglandin derivatives. The 13-cis prostaglandin derivatives exhibit prostaglandin-like pharmacological properties and are further useful as intermediates for the corresponding prostaglandin isomers having the normal 13-trans configuration.
Claims7
A 13-cis prostaglandin compound selected from the group of isomers having the formulas:
- ##STR24## wherein n is a whole integer of from two through eight;
- R.sup.1 is hydrogen, alkyl having from one through ten carbon atoms, chloroethyl, dichloroethyl, or trichloroethyl;
- R.sup.2 is hydrogen;
- R.sup.3 is oxo;
- and .about.OR.sup.4 is hydroxy or acid labile ether having from three through ten carbon atoms wherein the wavy bond line indicates either the .alpha. or .beta. configuration or isomer mixtures of the .alpha. and .beta. configurations;
- and mixtures of such isomers and pharmaceutically acceptable salts of such isomers and isomer mixtures wherein R.sup.1 is hydrogen.
3 more elements
Dependencies are inferred from the claim text.