Ionene modified small polymeric beads
AssigneeCalifornia Institute of Technology
InventorAlan Rembaum
Life of this patent
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Abstract
Linear ionene polyquaternary cationic polymeric segments are bonded by means of the Menshutkin reaction (quaternization) to biocompatible, extremely small, porous particles containing halide or tertiary amine sites which are centers for attachment of the segments. The modified beads in the form of emulsions or suspensions offer a large, positively-charged surface area capable of irreversibly binding polyanions such as heparin, DNA, RNA or bile acids to remove them from solution or of reversibly binding monoanions such as penicillin, pesticides, sex attractants and the like for slow release from the suspension.
Claims8
A composition of matter comprising:
- small, synthetic, organic, polymeric spherical particles having a diameter from 100 A. to 100 microns which are the cross-linked, addition polymerization product of a mono-unsaturated, acrylic monomer substituted with ionene reactive chloro, bromo, iodo or tertiary amine sites with 0.1 to 30% by weight of a diene or triene capable of addition polymerization with the unsaturated group of the acrylic monomer and having covalently bonded to at least one of said sites linear, polyquaternary ionene segments having an average charge of at least one intrapolymeric quaternary nitrogen for an average of every twelve chain atoms such that the halogen content of the segments is from 1 meg to 30 meg per gram of particle to form a particle of the structure:
- ##STR9## where R.sup.11 is methyl, R.sup.9 and R.sup.10 are divalent aliphatic, aromatic or heterocyclic groups containing at least 3 carbon atoms, or R.sup.9 combined with R.sup.11 form a cyclic group, W is chloro, bromo, or iodo and n is an integer.
Dependencies are inferred from the claim text.