Antibiotics designated XK-88 series
AssigneeAbbott Laboratories
InventorsTakashi Nara, Seigo Takasawa, Ryo Okachi, Isao Kawamoto, Mitsuyoshi Yamamoto, Seiji Sato, Tomoyasu Sato, Atsuko Morikawa
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Abstract
A novel series of antibiotics designated the XK-88 series are produced by culturing a microorganism belonging to the genus Streptomyces in a nutrient medium and thereafter recovering the antibiotics from the culture liquor.
Claims9
A composition of matter having antibacterial activity selected from the group consisting of XK-88-1, XK-88-2, XK-88-3 and XK-88-5 represented by the formula:
- ##STR7## wherein X is ##STR8## or --H;
- Y is --NH.sub.2 or --OH;
- and Z is --H or --OH;
- and wherein when X is ##STR9## Y and Z are --OH, said component being XK-88-1, or Y is NH.sub.2 and Z is OH, said component being XK-88-3;
- and when X is ##STR10## Y is NH.sub.2 and Z is --H, said component being XK-88-5;
- and when X is --H, Y is NH.sub.2 and Z is --H said component being XK-88-2;
- and the pharmaceutically acceptable acid addition salts thereof.
The antibiotic XK-88-1 of the formula:
- ##STR11##
The antibiotic XK-88-2 of the formula ##STR12##
The antibiotic XK-88-3 of the formula ##STR13##
The antibiotic XK-88-5 of the formula ##STR14##
Dependencies are inferred from the claim text.